Next time you boot up MLB 2K6 you should be prompted to download an update. This update should fix the nasty freezing which has been occurring.
Taken from the 2K Sports team:
Xbox 360 HDD issue with Major League Baseball 2K6
2K Sports has finalized a solution that solves the issue found with Xbox 360 HDD systems when playing Major League Baseball 2K6. The 2K Sports QA team pinpointed and confirmed with Microsoft a cache issue with replays that users with the HDD systems may encounter. The cache issue has been limited to less than 10% of the Major League Baseball 2K6 Xbox 360 users. When these machines are powered down during gameplay, the cache on the HDD may become corrupted and may result in the system “freeze” issue. 2K Sports has isolated the cause and has created a Title Update to correct this issue that is now available.
How do I access the Title Update?
A Title Update is available on Xbox Live free via the Xbox 360 Live Silver service that comes with every Xbox 360. NOTE – You are not required to have an Xbox Live Gold account to download this Title Update. Once you are connected to Xbox Live, you will just need to insert your Major League Baseball 2K6 game into your Xbox 360 console and a prompt will come up regarding an update available for this game. You can then select “Yes, update now” and the Title Update will be applied to your console. As precaution, we recommend that all users who use an HDD download this Title Update.
* If you’ve received an error while downloading the update, please try rebooting and downloading again.
We sincerely apologize for any inconvenience to your playing experience and we appreciate your understanding and support. Please stay tuned for further updates.
So there you go. You can go back to playing MLB without a pitch… sorry hitch.
Originally Written By: Toby Bodman